Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8546384 | 0.99 | PDE4A (0.54) | PDE4APDE4CPDE4DPDE4BMAPT | |
| SCHEMBL7444919 | 0.82 | PDE4A (0.71) | PDE4APDE4CPDE4DPDE4BMAPT | |
| SCHEMBL7437896 | 0.81 | PDE4A (0.69) | PDE4APDE4CPDE4DPDE4BMAPT | |
| SCHEMBL7441348 | 0.80 | PDE4A (0.55) | PDE4APDE4CPDE4DPDE4B | |
| SCHEMBL7436409 | 0.80 | PDE4A (0.53) | PDE4APDE4CPDE4DPDE4B | |
| SCHEMBL7450702 | 0.79 | PDE4A (0.60) | PDE4APDE4CPDE4DPDE4BMAPT | |
| SCHEMBL7436994 | 0.79 | PDE4A (0.63) | PDE4APDE4CPDE4DPDE4B | |
| SCHEMBL7443505 | 0.79 | PDE4A (0.59) | PDE4APDE4CPDE4DPDE4B | |
| Hydrochloric Acid SCHEMBL7438959 | 0.79 | PDE4A (0.52) | PDE4APDE4CPDE4DPDE4B | |
| SCHEMBL7448938 | 0.77 | PDE4A (0.60) | PDE4APDE4CPDE4DPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |