SCHEMBL7434783

SCHEMBL7434783

OCCCCc1csc2ccccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.67
SMN1; SMN2 Q16637 5/20 0.55
ALDH1A1 P00352 1/20 0.50
IDO1 P14902 1/20 0.49
MTNR1A P48039 1/20 0.46
CHRNA7 P36544 1/20 0.45
CRHBP P24387 1/20 0.44
CRHR2 Q13324 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
TAAR1 Q96RJ0 1/20 0.42
MAPT P10636 2/20 0.42
TP53 P04637 2/20 0.41
RXFP1 Q9HBX9 1/20 0.41
HDAC6 Q9UBN7 2/20 0.40
POLB P06746 1/20 0.40
HDAC1 Q13547 1/20 0.40
JUN P05412 1/20 0.39
MAPK8 P45983 1/20 0.39
MAPK9 P45984 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL79170 0.95 CYP2A6 (0.69) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL31462463 0.87 CYP2A6 (0.74) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL908324 0.87 CYP2A6 (0.74) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL48374 0.82 CYP2A6 (0.57) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL5540612 0.82 CYP2A6 (0.56) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL368354 0.82 CYP2A6 (0.56) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL9347766 0.81 CYP2A6 (0.55) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL9347729 0.81 CYP2A6 (0.55) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL17101656 0.81 CYP2A6 (0.62) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL5536097 0.81 CYP2A6 (0.55) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207677-B1 ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA H. LUNDBECK A/S (DK) 2001-03-27 US disclosed
US-6031099-A Piperidine derivates having anxiolytic effect H. LUNDBECK A/S (DK) 2000-02-29 US disclosed
US-5807871-A PSYCHOLOGICAL DISORDERS, ALZHEIMER OR PARKINSON DISEASE H. LUNDBECK A/S (DK) 1998-09-15 US disclosed
EP-0593511-B1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT LUNDBECK & CO AS H (DK) 1998-09-02 EP disclosed
EP-0859004-A1 Piperidine derivatives having anxiolytic effect H. LUNDBECK A/S (DK) 1998-08-19 EP disclosed
EP-0853085-A1 Piperidine derivatives having anxiolytic effect H. LUNDBECK A/S (DK) 1998-07-15 EP disclosed
US-5665725-A Piperidine derivatives having anxiolytic effect Lundbeck, H. (DK) 1997-09-09 US disclosed
EP-0593511-A1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT H. LUNDBECK A/S (DK) 1994-04-27 EP disclosed
WO-1992022554-A1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT H. LUNDBECK A/S (DK) 1992-12-23 WO disclosed
EP-0518805-A1 Piperidine derivatives H. LUNDBECK A/S (DK) 1992-12-16 EP disclosed