SCHEMBL908324

SCHEMBL908324

OCCc1csc2ccccc12

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.74
SMN1; SMN2 Q16637 5/20 0.60
ALDH1A1 P00352 1/20 0.54
IDO1 P14902 1/20 0.53
MTNR1A P48039 1/20 0.49
CHRNA7 P36544 1/20 0.49
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
MAPT P10636 2/20 0.46
TAAR1 Q96RJ0 1/20 0.45
TP53 P04637 2/20 0.44
RXFP1 Q9HBX9 1/20 0.44
HDAC6 Q9UBN7 2/20 0.43
POLB P06746 1/20 0.43
HDAC1 Q13547 1/20 0.42
JUN P05412 1/20 0.41
MAPK8 P45983 1/20 0.41
MAPK9 P45984 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31462463 1.00 CYP2A6 (0.74) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL79170 0.89 CYP2A6 (0.69) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL7434783 0.87 CYP2A6 (0.67) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL2248829 0.85 CYP2A6 (1.00) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL48374 0.80 CYP2A6 (0.57) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL277679 0.80 CYP2A6 (0.71) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL7845291 0.80 CYP2A6 (0.62) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL1304400 0.80 CYP2A6 (0.62) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL5546289 0.80 CYP2A6 (0.62) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A
SCHEMBL7427114 0.80 CYP2A6 (0.62) CYP2A6SMN1; SMN2ALDH1A1IDO1MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250171459-A1 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMA (US) 2025-05-29 US disclosed
US-20250122213-A1 OPIOID RECEPTOR MODULATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2025-04-17 US disclosed
US-12195478-B2 Opioid receptor modulators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2025-01-14 US disclosed
EP-4487913-A2 OPIOID RECEPTOR MODULATORS The Trustees Of Columbia University In The City Of New York (US) 2025-01-08 EP disclosed
EP-4476227-A1 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME Vertex Pharmaceuticals Incorporated (US) 2024-12-18 EP disclosed
EP-3224261-B1 OPIOID RECEPTOR MODULATORS UNIV COLUMBIA (US) 2024-09-18 EP disclosed
US-11840541-B2 Opioid receptor modulators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-12-12 US disclosed
US-11840541-B2 Opioid receptor modulators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-12-12 US disclosed
US-11840541-B2 Opioid receptor modulators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-12-12 US disclosed
US-20230271976-A1 OPIOID RECEPTOR MODULATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-08-31 US disclosed
EP-0593511-B1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT LUNDBECK & CO AS H (DK) 1998-09-02 EP disclosed
EP-0859004-A1 Piperidine derivatives having anxiolytic effect H. LUNDBECK A/S (DK) 1998-08-19 EP disclosed
EP-0853085-A1 Piperidine derivatives having anxiolytic effect H. LUNDBECK A/S (DK) 1998-07-15 EP disclosed
US-5665725-A Piperidine derivatives having anxiolytic effect Lundbeck, H. (DK) 1997-09-09 US disclosed
EP-0761666-A2 Antidepressant 1-arylalkyl-4-(alkoxypyridinyl)- or 4-(alkoxypyrimidinyl)piperazine derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 1997-03-12 EP disclosed
EP-0593511-A1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT H. LUNDBECK A/S (DK) 1994-04-27 EP disclosed
WO-1992022554-A1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT H. LUNDBECK A/S (DK) 1992-12-23 WO disclosed
EP-0518805-A1 Piperidine derivatives H. LUNDBECK A/S (DK) 1992-12-16 EP disclosed
US-4036842-A FRIEDEL CRAFTS CATALYST AMERICAN HOME PRODUCTS CORPORATION (US) 1977-07-19 US disclosed
US-4021451-A P-(3,4-DIHYDRO-1-METHYL-1H-(1)BENZOTHIENO(2,3-C)PYRAN-1-YL)PHENYL) -ACETIC ACID AMERICAN HOME PRODUCTS CORPORATION (US) 1977-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12195478-B2 Opioid receptor modulators OPRM1, OPRL1, OPRD1 CYP2A6 627/4885SMN1; SMN2 3917/4885ALDH1A1 2316/4885
US-20250171459-A1 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME APOL1, PDXK, PNLIP CYP2A6 4589/4885SMN1; SMN2 617/4885ALDH1A1 3122/4885
US-20250122213-A1 OPIOID RECEPTOR MODULATORS OPRM1, OPRL1, OPRD1 CYP2A6 627/4885SMN1; SMN2 3917/4885ALDH1A1 2316/4885
US-20230271976-A1 OPIOID RECEPTOR MODULATORS OPRM1, OPRL1, OPRD1 CYP2A6 627/4885SMN1; SMN2 3917/4885ALDH1A1 2316/4885
US-11840541-B2 Opioid receptor modulators OPRM1, OPRL1, OPRD1 CYP2A6 514/4885SMN1; SMN2 4640/4885ALDH1A1 2434/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.