SCHEMBL7434892

SCHEMBL7434892

COP(=O)(OC)C(O)[C@H](CC1CCCCC1)N[C@@H](Cc1c[nH]cn1)C(=O)NC(=O)CC(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
REN P00797 20/20 0.33
PGC P20142 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7434900 0.90 REN (0.39) RENPGC
SCHEMBL7435729 0.90 REN (0.37) RENPGC
SCHEMBL7427804 0.87 REN (0.34) REN
SCHEMBL7433349 0.86 REN (0.42) REN
SCHEMBL7429052 0.82 REN (0.37) RENPGC
SCHEMBL7435734 0.81 REN (0.46) RENPGC
SCHEMBL7427810 0.78 REN (0.42) REN
SCHEMBL7427417 0.76 REN (0.50) REN
SCHEMBL7428035 0.73 REN (0.51) REN
SCHEMBL7429041 0.73 REN (0.45) RENPGC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1989007940-A1 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF E.R. SQUIBB & SONS, INC. (US) 1989-09-08 WO claimed
EP-0331105-A2 1,2-Hydroxy phosphonates and derivatives thereof E.R. Squibb & Sons, Inc. (US) 1989-09-06 EP claimed
US-5217958-A Hypotensive agents E. R. SQUIBB & SONS, INC. (US) 1993-06-08 US disclosed
WO-1989007940-A1 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF E.R. SQUIBB & SONS, INC. (US) 1989-09-08 WO disclosed
EP-0331105-A2 1,2-Hydroxy phosphonates and derivatives thereof E.R. Squibb & Sons, Inc. (US) 1989-09-06 EP disclosed