Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.57 |
| ▸ | MEN1 | O00255 | 9/20 | 0.57 |
| ▸ | PDE5A | O76074 | 8/20 | 0.57 |
| ▸ | GBA1 | P04062 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431460 | 0.84 | KMT2A (0.61) | KMT2AMEN1PDE5AGBA1ATM | |
| SCHEMBL7610307 | 0.80 | LATS1 (0.46) | KMT2AMEN1PDE5AGBA1MAPT | |
| SCHEMBL7608491 | 0.78 | MAPK1 (0.44) | KMT2AMEN1PDE5AGBA1MAPK1 | |
| SCHEMBL7608895 | 0.78 | MAPK1 (0.44) | KMT2AMEN1PDE5AGBA1MAPK1 | |
| SCHEMBL1083763 | 0.74 | PDE5A (1.00) | KMT2AMEN1PDE5AGBA1ATM | |
| SCHEMBL7431532 | 0.72 | KMT2A (0.77) | KMT2AMEN1PDE5AGBA1ATM | |
| SCHEMBL7431547 | 0.70 | PDE5A (0.66) | KMT2AMEN1PDE5AGBA1ATM | |
| SCHEMBL7432870 | 0.70 | PDE5A (0.69) | KMT2AMEN1PDE5AGBA1ATM | |
| SCHEMBL7277479 | 0.70 | PDE5A (1.00) | KMT2AMEN1PDE5AGBA1ATM | |
| SCHEMBL1084183 | 0.70 | MEN1 (0.89) | KMT2AMEN1PDE5AGBA1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | claimed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |