Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.89 |
| ▸ | LMNA | P02545 | 6/20 | 0.89 |
| ▸ | MAPT | P10636 | 3/20 | 0.89 |
| ▸ | PDE5A | O76074 | 9/20 | 0.83 |
| ▸ | GBA1 | P04062 | 2/20 | 0.83 |
| ▸ | ATM | Q13315 | 1/20 | 0.83 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.75 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.75 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.75 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.69 |
| ▸ | APP | P05067 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.66 |
| ▸ | TSHR | P16473 | 4/20 | 0.66 |
| ▸ | USP2 | O75604 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2583554 | 0.94 | MEN1 (1.00) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL1083763 | 0.91 | PDE5A (1.00) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL27899411 | 0.91 | MEN1 (0.83) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL12176337 | 0.91 | PDE5A (0.85) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL3459669 | 0.89 | PDE5A (0.85) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL2580707 | 0.88 | MEN1 (0.77) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL2583256 | 0.87 | PDE5A (0.90) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL2590764 | 0.87 | MEN1 (0.81) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL12176300 | 0.87 | MEN1 (0.81) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL4867531 | 0.87 | MEN1 (0.76) | MEN1KMT2ALMNAMAPTPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |