Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233813 | 0.57 | PDE3B (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9174564 | 0.54 | PDE5A (0.36) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8569375 | 0.48 | PARP1 (0.32) | — | |
| SCHEMBL8312414 | 0.46 | — | — | |
| SCHEMBL10774841 | 0.46 | — | — | |
| SCHEMBL7485228 | 0.45 | KMT2A (0.49) | PDE5A | |
| SCHEMBL5555023 | 0.45 | L3MBTL1 (0.51) | — | |
| SCHEMBL4804534 | 0.45 | — | — | |
| SCHEMBL2992030 | 0.45 | — | — | |
| SCHEMBL1190965 | 0.45 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |