Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5421535 | 0.93 | HSD17B10 (0.52) | KMT2ALMNAMEN1TDP1HTR2C | |
| SCHEMBL7326732 | 0.90 | HSD17B10 (0.52) | KMT2ALMNAMEN1TDP1HTR2C | |
| SCHEMBL6585617 | 0.84 | CSNK2B (0.38) | LMNAHTR2CHTR2A | |
| SCHEMBL7434089 | 0.80 | BCHE (0.45) | KMT2ALMNAMEN1TDP1HTR2C | |
| SCHEMBL7433257 | 0.78 | KMT2A (0.43) | KMT2ALMNAMEN1TDP1HTR2C | |
| SCHEMBL7433263 | 0.78 | KMT2A (0.43) | KMT2ALMNAMEN1TDP1HTR2C | |
| SCHEMBL7424620 | 0.78 | CDK4 (0.45) | KMT2ALMNAMEN1TDP1HTR2C | |
| SCHEMBL6581005 | 0.75 | POLL (0.39) | HTR2CHTR2ACDK4CCND1 | |
| SCHEMBL5847534 | 0.73 | HSD17B10 (0.48) | KMT2ALMNAMEN1TDP1HTR2C | |
| SCHEMBL3542992 | 0.73 | HTR2C (0.69) | KMT2ALMNAMEN1TDP1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997831-A | Antagonists of 5-hydroxytryptamine receptors | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0357417-A1 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-03-07 | — | — | EP | disclosed |