Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.58 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.58 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11708659 | 0.90 | CES1 (0.61) | METAP1PARP10PARP11ELANESRD5A1 | |
| SCHEMBL7841271 | 0.90 | METAP1 (0.51) | METAP1PARP10PARP11ELANESRD5A1 | |
| SCHEMBL4148213 | 0.89 | METAP1 (0.50) | METAP1PARP10PARP11ELANESRD5A1 | |
| SCHEMBL7491470 | 0.87 | MAPK14 (0.56) | METAP1MIFALDH1A1SMN1; SMN2MAPK14 | |
| SCHEMBL31124706 | 0.86 | METAP1 (0.71) | METAP1PARP10PARP11ELANESRD5A1 | |
| SCHEMBL11891506 | 0.86 | METAP1 (0.71) | METAP1PARP10PARP11ELANESRD5A1 | |
| SCHEMBL10427201 | 0.86 | METAP1 (0.71) | METAP1PARP10PARP11ELANESRD5A1 | |
| SCHEMBL7496441 | 0.86 | MIF (0.48) | METAP1PARP10PARP11ELANESRD5A1 | |
| SCHEMBL7486660 | 0.86 | ALDH1A1 (0.50) | METAP1PARP10PARP11ELANESRD5A1 | |
| SCHEMBL19422232 | 0.85 | PARP10 (0.55) | METAP1PARP10PARP11ELANESRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020248943-A1 | NITROGEN-CONTAINING COMPOUND, ELECTRONIC COMPONENT AND ELECTRONIC DEVICE | 陕西莱特光电材料股份有限公司 | 2020-12-17 | — | — | WO | disclosed |
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| EP-0984963-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-11 | — | — | EP | disclosed |
| US-6162808-A | Compounds | ASTRAZENECA U.K. LIMITED (GB) | 2000-12-19 | — | — | US | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |
| EP-0589322-B1 | 5-Oxo-dibenzo[a,d]cyclohepta-1,4-dienes and their use as retroviral agents | BAYER AG (DE) | 1997-03-19 | — | — | EP | disclosed |
| US-5457108-A | Viricides for treating retroviruses | BAYER AKTIENGESELLSCHAFT (DE) | 1995-10-10 | — | — | US | disclosed |
| EP-0589322-A1 | 5-Oxo-dibenzo[a,d]cyclohepta-1,4-dienes and their use as retroviral agents | BAYER AG (DE) | 1994-03-30 | — | — | EP | disclosed |