SCHEMBL7435820

SCHEMBL7435820

Fc1ccc(-n2cc(CCCCN3CCC4(CC3)OCc3ccccc34)c3cc(F)ccc32)cc1

nearest known ligand 0.87

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TMEM97 Q5BJF2 1/20 0.87
SIGMAR1 Q99720 1/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8687455 0.93 TMEM97 (0.87) TMEM97SIGMAR1
Siramesine SCHEMBL29358736 0.93 TMEM97 (1.00) TMEM97SIGMAR1
Siramesine SCHEMBL2090079 0.93 TMEM97 (1.00) TMEM97SIGMAR1
Siramesine SCHEMBL6198150 0.92 TMEM97 (0.98) TMEM97SIGMAR1
Siramesine SCHEMBL29888883 0.92 TMEM97 (0.98) TMEM97SIGMAR1
Siramesine SCHEMBL6198062 0.92 TMEM97 (0.98) TMEM97SIGMAR1
Siramesine SCHEMBL7495013 0.92 TMEM97 (0.98) TMEM97SIGMAR1
SCHEMBL7440500 0.90 TMEM97 (0.88) TMEM97SIGMAR1
SCHEMBL7436838 0.90 TMEM97 (0.71) TMEM97SIGMAR1
SCHEMBL6195635 0.90 TMEM97 (0.87) TMEM97SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593511-B1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT LUNDBECK & CO AS H (DK) 1998-09-02 EP claimed
US-5665725-A Piperidine derivatives having anxiolytic effect Lundbeck, H. (DK) 1997-09-09 US claimed
EP-0518805-A1 Piperidine derivatives H. LUNDBECK A/S (DK) 1992-12-16 EP claimed
WO-2002102387-A1 TREATMENT OF NEUROPATHIC PAIN H. LUNDBECK A/S (DK) 2002-12-27 WO disclosed
US-6031099-A Piperidine derivates having anxiolytic effect H. LUNDBECK A/S (DK) 2000-02-29 US disclosed
EP-0593511-B1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT LUNDBECK & CO AS H (DK) 1998-09-02 EP disclosed
EP-0859004-A1 Piperidine derivatives having anxiolytic effect H. LUNDBECK A/S (DK) 1998-08-19 EP disclosed
EP-0853085-A1 Piperidine derivatives having anxiolytic effect H. LUNDBECK A/S (DK) 1998-07-15 EP disclosed
US-5665725-A Piperidine derivatives having anxiolytic effect Lundbeck, H. (DK) 1997-09-09 US disclosed
EP-0518805-A1 Piperidine derivatives H. LUNDBECK A/S (DK) 1992-12-16 EP disclosed