Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Siramesine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.98 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Siramesine SCHEMBL2090079 | 0.99 | TMEM97 (1.00) | TMEM97SIGMAR1 | |
| Siramesine SCHEMBL29358736 | 0.99 | TMEM97 (1.00) | TMEM97SIGMAR1 | |
| Siramesine SCHEMBL29888883 | 0.98 | TMEM97 (0.98) | TMEM97SIGMAR1 | |
| Siramesine SCHEMBL6198062 | 0.98 | TMEM97 (0.98) | TMEM97SIGMAR1 | |
| Siramesine SCHEMBL7495013 | 0.98 | TMEM97 (0.98) | TMEM97SIGMAR1 | |
| SCHEMBL7440500 | 0.93 | TMEM97 (0.88) | TMEM97SIGMAR1 | |
| SCHEMBL8687455 | 0.92 | TMEM97 (0.87) | TMEM97SIGMAR1 | |
| SCHEMBL6195635 | 0.92 | TMEM97 (0.87) | TMEM97SIGMAR1 | |
| SCHEMBL7435820 | 0.92 | TMEM97 (0.87) | TMEM97SIGMAR1 | |
| SCHEMBL7436300 | 0.89 | TMEM97 (0.82) | TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044202-B1 | 1'- 4- 1- (4-FLUOROPHENYL)- 1H-INDOLE-3-YL] -1-BUTYL]-SPIRO ISOBENZOFURAN- 1(3H),4'- PIPERIDINE] HYDROHALOGENIDES | LUNDBECK & CO AS H (DK) | 2005-02-09 | — | — | EP | disclosed |
| US-6844352-B2 | 1′-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4′-piperidine] hydrohalogenides | H. LUNDBECK A/S (DK) | 2005-01-18 | — | — | US | disclosed |
| US-20030055074-A1 | 1'-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine] hydrohalogenides | H. LUNDBECK A/S (DK) | 2003-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055074-A1 | 1'-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine] hydrohalogenides | HTR1D, TPH1, HTR4 | SIGMAR1 210/4885TMEM97 1196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.