Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10990414 | 0.83 | GAA (0.67) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL28349386 | 0.80 | GAA (0.62) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL867675 | 0.80 | GAA (0.62) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL15320452 | 0.80 | GAA (0.62) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL28612690 | 0.80 | GAA (0.62) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL26634530 | 0.80 | GAA (0.62) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL27798357 | 0.79 | SIGMAR1 (0.62) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL9524478 | 0.78 | GAA (0.61) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL31230952 | 0.78 | GAA (0.61) | GAAMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL11707747 | 0.78 | GAA (0.61) | GAAMEN1KMT2ATSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049548-A | Hypotensives | MERCK & CO., INC. (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0389127-A1 | Renin-inhibitory di-, tri-, and tetrapeptides | MERCK & CO. INC. (US) | 1990-09-26 | — | — | EP | disclosed |