Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 9/20 | 0.45 |
| ▸ | JAK1 | P23458 | 7/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348883 | 0.82 | PDE4B (0.82) | PDE4BJAK3JAK1 | |
| SCHEMBL4345837 | 0.81 | PDE4B (0.80) | PDE4BJAK3JAK1MEN1ALDH1A1 | |
| SCHEMBL14115714 | 0.79 | PDE4B (0.60) | PDE4BCHEK1CHEK2JAK3JAK1 | |
| SCHEMBL8311913 | 0.78 | PDE4B (0.59) | PDE4BCHEK1CHEK2JAK3JAK1 | |
| SCHEMBL2772466 | 0.77 | PDE4B (0.58) | PDE4BCHEK1CHEK2JAK3JAK1 | |
| SCHEMBL4740302 | 0.77 | PDE4B (0.58) | PDE4BCHEK1CHEK2JAK3JAK1 | |
| SCHEMBL2773376 | 0.75 | PDE4B (1.00) | PDE4BCHEK1CHEK2JAK3JAK1 | |
| SCHEMBL5173971 | 0.74 | PDE4B (0.55) | PDE4BCHEK1CHEK2JAK3JAK1 | |
| SCHEMBL14353567 | 0.73 | NUDT1 (0.64) | PDE4BCHEK1CHEK2JAK3MEN1 | |
| SCHEMBL30424537 | 0.73 | NUDT1 (0.64) | PDE4BCHEK1CHEK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355234-A1 | Pyrazolopyridine derivatives as antiatherosclerotic and antihypercholesterolemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-28 | — | — | EP | disclosed |