Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 4/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 4/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 4/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 16/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.68 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11318875 | 0.84 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7344243 | 0.81 | PDE3B (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7435984 | 0.79 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11082512 | 0.79 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11092896 | 0.79 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11085890 | 0.77 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7427721 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL31123125 | 0.77 | PDE3B (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7426790 | 0.77 | PDE3B (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11329147 | 0.76 | PDE3B (0.80) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4647564-A | PYRIDAZINONE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0161918-A2 | Indoline and 2-indolinone derivatives | ELI LILLY AND COMPANY (US) | 1985-11-21 | — | — | EP | disclosed |