Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 13/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9787338 | 0.86 | HCAR2 (0.41) | PDE3BPDE3AHCAR2ATMSMYD3 | |
| SCHEMBL7432992 | 0.85 | PDE3B (0.62) | PDE3BPDE3AHCAR2ATMPDE4A | |
| SCHEMBL7446222 | 0.79 | PDE3B (0.72) | PDE3BPDE3AATMPDE4APDE4B | |
| SCHEMBL7443821 | 0.71 | PDE3B (0.60) | PDE3BPDE3AHCAR2PDE4APDE4B | |
| SCHEMBL7436437 | 0.67 | HPGD (0.44) | PDE3BPDE3AHTTRAB9A | |
| SCHEMBL7441965 | 0.64 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7439917 | 0.64 | PDE4A (0.43) | PDE3BPDE3AATMPDE4APDE4B | |
| SCHEMBL7434193 | 0.64 | PDE3B (0.70) | PDE3BPDE3AHCAR2PDE4APDE4B | |
| SCHEMBL12599363 | 0.64 | HCAR2 (0.62) | HCAR2ATMSMYD3HTTRAB9A | |
| Ammonia Solution, Strong SCHEMBL27341465 | 0.63 | HCAR2 (0.96) | HCAR2ATMSMYD3HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0059948-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-09-15 | — | — | EP | disclosed |