Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436267 | 0.86 | PDE3B (0.45) | HCAR2ATMSMYD3HTTRAB9A | |
| SCHEMBL7432992 | 0.71 | PDE3B (0.62) | HCAR2ATMSMYD3HTTRAB9A | |
| SCHEMBL9787352 | 0.68 | HCAR2 (0.39) | HCAR2HTTPDE3BPDE3A | |
| SCHEMBL9787284 | 0.68 | HPGD (0.43) | HTTRAB9A | |
| SCHEMBL9787294 | 0.65 | KMT2A (0.39) | HTTCCNCCDK8 | |
| SCHEMBL7446222 | 0.64 | PDE3B (0.72) | ATMPDE3BPDE3A | |
| SCHEMBL9787143 | 0.63 | PDE3B (0.71) | PDE3BPDE3A | |
| SCHEMBL12599363 | 0.63 | HCAR2 (0.62) | HCAR2ATMSMYD3HTTRAB9A | |
| Ammonia Solution, Strong SCHEMBL27341465 | 0.63 | HCAR2 (0.96) | HCAR2ATMSMYD3HTTRAB9A | |
| SCHEMBL7431570 | 0.61 | PDE3B (0.56) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999365-A | Preventing damage which occurs to heart tissue when oxygen is reintroduced after a heart attack | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0284925-A2 | Use of imidazol-2-thiones for the preparation of a medicament for reducing myocardial stunning | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-05 | — | — | EP | disclosed |