SCHEMBL7436635

SCHEMBL7436635

CC(C)(C)OC(=O)CC(NC(=O)OCc1ccccc1)C(=O)Cn1nnc(-c2cccc3ccccc23)n1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
CASP1 P29466 14/20 0.46
TP53 P04637 1/20 0.42
KLK7 P49862 1/20 0.39
KLK5 Q9Y337 1/20 0.39
SYK P43405 1/20 0.39
NPC1 O15118 1/20 0.39
HPGD P15428 1/20 0.39
RAB9A P51151 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7431049 0.91 CYP1A2 (0.49) CYP1A2CYP2C9CYP2C19CASP1TP53
SCHEMBL7445867 0.89 CASP1 (0.54) CYP1A2CYP2C9CYP2C19CASP1
SCHEMBL7438698 0.89 CYP1A2 (0.58) CYP1A2CYP2C9CYP2C19CASP1TP53
SCHEMBL7434041 0.89 CYP1A2 (0.47) CYP1A2CYP2C9CYP2C19CASP1TP53
SCHEMBL7437630 0.88 CYP1A2 (0.56) CYP1A2CYP2C9CYP2C19CASP1TP53
SCHEMBL7445776 0.87 CYP1A2 (0.46) CYP1A2CYP2C9CYP2C19CASP1TP53
SCHEMBL7431018 0.87 CYP1A2 (0.51) CYP1A2CYP2C9CYP2C19CASP1TP53
SCHEMBL7429734 0.86 CYP1A2 (0.46) CYP1A2CYP2C9CYP2C19CASP1TP53
SCHEMBL7442251 0.85 SMN1; SMN2 (0.49) CYP1A2CYP2C9CYP2C19CASP1TP53
SCHEMBL7443556 0.85 CYP1A2 (0.47) CYP1A2CYP2C9CYP2C19CASP1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5710153-A INTERLEUKIN CONVERTING ENZYME INHIBITORS ONO PHRAMACEUTICAL CO., LTD. (JP) 1998-01-20 US disclosed
EP-0761680-A2 Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity ONO PHARMACEUTICAL CO., LTD. (JP) 1997-03-12 EP disclosed