Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30393322 | 1.00 | PDE10A (0.52) | PDE10ASMN1; SMN2MEN1KMT2AMAOA | |
| SCHEMBL405970 | 0.80 | CSNK1A1 (0.51) | PDE10ASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL22987414 | 0.79 | PDE10A (0.52) | PDE10ASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL363210 | 0.79 | KDM4E (0.54) | PDE10ASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL29646392 | 0.79 | PDE10A (0.52) | PDE10ASMN1; SMN2MEN1KMT2AMAOA | |
| SCHEMBL15263323 | 0.79 | PDE10A (0.52) | PDE10ASMN1; SMN2MEN1KMT2AMAOA | |
| SCHEMBL29646373 | 0.79 | PDE10A (0.52) | PDE10ASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL11726219 | 0.79 | PDE10A (0.49) | PDE10ASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL31167564 | 0.78 | CHEK1 (0.37) | PDE10ASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL12225113 | 0.78 | HTT (0.43) | PDE10ASMN1; SMN2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575442-B1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NOVO NORDISK AS (DK) | 1995-12-27 | — | — | EP | disclosed |
| EP-0575442-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | NOVO NORDISK AS (DK) | 1993-12-29 | — | — | EP | disclosed |
| US-5260298-A | Psychopharmaceuticals | NOVO NORDISK A/S (DK) | 1993-11-09 | — | — | US | disclosed |
| WO-1992015591-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NOVO NORDISK A/S (DK) | 1992-09-17 | — | — | WO | disclosed |
| US-4053600-A | ANTIINFLAMMATORY AGENTS, HYPOTENSIVE AGENTS | SANDOZ, INC. (US) | 1977-10-11 | — | — | US | disclosed |