Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436879 | 0.79 | PDE10A (0.52) | KDM4EHSD17B10LMNAPOLBMAPT | |
| SCHEMBL15263323 | 0.79 | PDE10A (0.52) | KDM4EHSD17B10LMNAPOLBMAPT | |
| SCHEMBL29646392 | 0.79 | PDE10A (0.52) | KDM4EHSD17B10LMNAPOLBMAPT | |
| SCHEMBL30393322 | 0.79 | PDE10A (0.52) | KDM4EHSD17B10LMNAPOLBMAPT | |
| SCHEMBL29646373 | 0.79 | PDE10A (0.52) | KDM4EHSD17B10LMNAPOLBMAPT | |
| SCHEMBL22987414 | 0.79 | PDE10A (0.52) | KDM4EHSD17B10LMNAPOLBMAPT | |
| SCHEMBL11726219 | 0.79 | PDE10A (0.49) | KDM4EHSD17B10LMNAPOLBMAPT | |
| SCHEMBL12838246 | 0.74 | PDE10A (0.67) | KDM4EHSD17B10LMNAPOLBMAPT | |
| SCHEMBL11728253 | 0.73 | HTR3A (0.62) | KMT2A | |
| SCHEMBL11726461 | 0.72 | PDE10A (0.46) | KDM4EHSD17B10LMNATP53PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |