Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.53 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.53 |
| ▸ | PTPRA | P18433 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561828 | 0.92 | TSHR (0.51) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL2597769 | 0.92 | TSHR (0.51) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL2375614 | 0.86 | TSHR (0.57) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL2375620 | 0.86 | TSHR (0.57) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL28030272 | 0.85 | SMN1; SMN2 (0.54) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL28030840 | 0.85 | SMN1; SMN2 (0.54) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL6949050 | 0.84 | SMN1; SMN2 (0.53) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL6949056 | 0.84 | SMN1; SMN2 (0.53) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL27917108 | 0.82 | SMN1; SMN2 (0.51) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT | |
| SCHEMBL27921610 | 0.82 | SMN1; SMN2 (0.51) | TSHRSMN1; SMN2CYP1A2CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0389127-A1 | Renin-inhibitory di-, tri-, and tetrapeptides | MERCK & CO. INC. (US) | 1990-09-26 | — | — | EP | disclosed |