Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517495 | 0.87 | CA2 (0.56) | CA2ALOX5APFEN1SLC22A12AGTR2 | |
| SCHEMBL27537443 | 0.81 | CA2 (0.50) | CA2ALOX5APFEN1SLC22A12AGTR2 | |
| SCHEMBL3141420 | 0.79 | KDM1A (0.55) | CA2ALOX5APFEN1SLC22A12LMNA | |
| SCHEMBL28749290 | 0.77 | CA2 (0.60) | CA2ALOX5APFEN1SLC22A12PTGS1 | |
| SCHEMBL688320 | 0.72 | PTPN11 (0.61) | CA2SMN1; SMN2 | |
| SCHEMBL27595682 | 0.71 | CA2 (0.63) | CA2LMNAMCOLN3CA12CA9 | |
| SCHEMBL27514473 | 0.71 | KDM1A (0.59) | CA2PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL10622905 | 0.71 | CA2 (0.61) | CA2ALOX5APFEN1SLC22A12PTGS1 | |
| SCHEMBL12054691 | 0.71 | CA2 (0.66) | CA2PTGS1PTGS2 | |
| SCHEMBL31377994 | 0.70 | SLC22A12 (0.61) | CA2SLC22A12PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| CN-1268117-A | Novel inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis | DU PONT PHARM CO (US) | 2000-09-27 | — | — | CN | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |