Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.46 |
| ▸ | CCND1 | P24385 | 19/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.45 |
| ▸ | CDK2 | P24941 | 10/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446420 | 0.78 | CDK4 (0.49) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5707841 | 0.76 | CDK4 (0.46) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5600331 | 0.73 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965911 | 0.72 | CRHR1 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8122461 | 0.72 | CDK4 (0.51) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5600433 | 0.72 | CRHR1 (0.57) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5599666 | 0.71 | CDK4 (0.54) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7953100 | 0.71 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5611027 | 0.70 | CDK4 (0.55) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7044979 | 0.70 | CDK4 (0.55) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149583-A2 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | Pfizer Products Inc. (US) | 2001-10-31 | — | — | EP | claimed |