Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | RAB9A | P51151 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439136 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7442267 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7438701 | 0.84 | CYP1A2 (0.48) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7437909 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7431022 | 0.82 | CYP1A2 (0.47) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7437870 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7440427 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7429538 | 0.79 | TDP1 (0.40) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7437714 | 0.79 | CYP1A2 (0.43) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7433069 | 0.79 | TDP1 (0.39) | SMN1; SMN2ALDH1A1LMNAHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |