Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437714 | 0.93 | CYP1A2 (0.43) | SMN1; SMN2HTTTHRBMAPTCYP1A2 | |
| SCHEMBL7431022 | 0.93 | CYP1A2 (0.47) | SMN1; SMN2HTTTHRBMAPTCYP1A2 | |
| SCHEMBL7438701 | 0.93 | CYP1A2 (0.48) | SMN1; SMN2HTTTHRBMAPTCYP1A2 | |
| SCHEMBL7439136 | 0.92 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTTHRBMAPTCYP1A2 | |
| SCHEMBL7439108 | 0.92 | CYP1A2 (0.41) | SMN1; SMN2HTTTHRBMAPTCYP1A2 | |
| SCHEMBL7445782 | 0.88 | CYP1A2 (0.35) | SMN1; SMN2HTTTHRBMAPTCYP1A2 | |
| SCHEMBL7433917 | 0.87 | AVPR2 (0.41) | THRBMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7432463 | 0.87 | HPGD (0.38) | THRBMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7434576 | 0.87 | LNPEP (0.38) | SMN1; SMN2HTTTHRBMAPTCYP1A2 | |
| SCHEMBL7431147 | 0.87 | MAPT (0.40) | SMN1; SMN2HTTTHRBMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |