Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.82 |
| ▸ | ADAM17 | P78536 | 20/20 | 0.82 |
| ▸ | MMP13 | P45452 | 19/20 | 0.82 |
| ▸ | MMP9 | P14780 | 3/20 | 0.67 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.67 |
| ▸ | MMP3 | P08254 | 2/20 | 0.67 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.67 |
| ▸ | MMP2 | P08253 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500981 | 1.00 | MMP1 (0.82) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6504024 | 0.92 | MMP1 (0.84) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6499747 | 0.92 | MMP1 (0.82) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL7440409 | 0.91 | MMP1 (1.00) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL3941937 | 0.91 | MMP1 (1.00) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6500803 | 0.90 | MMP1 (0.81) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL7431896 | 0.90 | MMP1 (0.81) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6757482 | 0.90 | MMP1 (0.78) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6500210 | 0.90 | MMP1 (0.68) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL3945436 | 0.89 | MMP1 (1.00) | MMP1ADAM17MMP13MMP9ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-A2 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044709-A2 | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |