Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.52 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 5/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.39 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84043 | 0.82 | PDE2A (0.53) | PDE2ACES2CES1ALDH1A1TSHR | |
| SCHEMBL16626077 | 0.82 | CES2 (0.45) | PDE2ACES2CES1ALDH1A1TSHR | |
| SCHEMBL2857448 | 0.81 | ESR1 (0.38) | — | |
| SCHEMBL10234326 | 0.80 | TSHR (0.46) | PDE2AALDH1A1TSHRKIF11AKR1C3 | |
| Ammonia Solution, Strong SCHEMBL27642816 | 0.80 | PDE2A (0.52) | PDE2ACES2CES1ALDH1A1TSHR | |
| SCHEMBL17722885 | 0.80 | TSHR (0.46) | PDE2AALDH1A1TSHRKIF11AKR1C3 | |
| SCHEMBL24816538 | 0.78 | PDE2A (0.36) | PDE2A | |
| SCHEMBL4964395 | 0.78 | PDE2A (0.50) | PDE2ACES2CES1ALDH1A1TSHR | |
| SCHEMBL22899446 | 0.78 | PDE2A (0.55) | PDE2ACES2CES1ALDH1A1TSHR | |
| SCHEMBL342466 | 0.78 | PTPN5 (0.55) | PDE2ACES2CES1ACP3KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008129319-A1 | SALTS OF OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |