Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30753564 | 1.00 | DPP4 (0.44) | DPP4PIN1DPP7DPP8CYP3A4 | |
| SCHEMBL897883 | 1.00 | DPP4 (0.44) | DPP4PIN1DPP7DPP8CYP3A4 | |
| SCHEMBL30378432 | 1.00 | DPP4 (0.44) | DPP4PIN1DPP7DPP8CYP3A4 | |
| Tert-Butylamine SCHEMBL898670 | 0.94 | DPP4 (0.43) | DPP4PIN1DPP7DPP8CYP3A4 | |
| SCHEMBL13084120 | 0.89 | DPP4 (0.42) | DPP4DPP7DPP8CYP3A4NPC1 | |
| SCHEMBL6697319 | 0.88 | DPP4 (0.39) | DPP4PIN1DPP7CYP3A4NPC1 | |
| SCHEMBL344346 | 0.83 | CTRB1 (0.53) | DPP4PIN1 | |
| SCHEMBL344345 | 0.83 | CTRB1 (0.53) | DPP4PIN1 | |
| SCHEMBL15114869 | 0.82 | DPP4 (0.37) | DPP4DPP7DPP8CYP3A4NPC1 | |
| SCHEMBL15108794 | 0.82 | DPP4 (0.37) | DPP4DPP7DPP8CYP3A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118063351-B | Green synthesis of chiral beta amino acids using biological enzymes and immobilized aminotransferase used | 北京元延医药科技股份有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-118063351-A | Green synthesis of chiral beta amino acids using biological enzymes and immobilized aminotransferase used | 北京元延医药科技股份有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117467733-B | High chiral purity sitagliptin and method for preparing same by using immobilized transaminase | 北京元延医药科技股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117467733-A | High chiral purity sitagliptin and method for preparing same by using immobilized transaminase | 北京元延医药科技股份有限公司 | 2024-01-30 | — | — | CN | disclosed |
| WO-2023175492-A1 | NOVEL INTERMEDIATES AND ITS USE IN MANUFACTURING OF SITAGLIPTIN | HIKAL LIMITED (IN) | 2023-09-21 | — | — | WO | disclosed |
| EP-2802554-B1 | PREPARATION OF OPTICALLY PURE ß-AMINO ACID TYPE ACTIVE PHARMACEUTICAL INGREDIENTS AND INTERMEDIATES THEREOF | LEK PHARMACEUTICALS (SI) | 2018-04-25 | — | — | EP | disclosed |
| US-20180086765-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | KYUNG DONG PHARM. CO., LTD. (KR) | 2018-03-29 | — | — | US | disclosed |
| EP-2861598-B1 | NEW SYNTHETIC ROUTE FOR THE PREPARATION OF ß-AMINOBUTYRYL SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,4]DIAZOLO[4,3-a]PYRAZIN-7-YL COMPOUNDS | LEK PHARMACEUTICALS (SI) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016110750-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | LEE PHARMA LIMITED (IN) | 2016-07-14 | — | — | WO | disclosed |
| US-9388188-B2 | Synthetic route for the preparation of β-aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha ]pyrazin-7-yl compounds | LEK PHARMACEUTICALS D.D. (SI) | 2016-07-12 | — | — | US | disclosed |
| US-20120108598-A1 | SITAGLIPTIN SYNTHESIS | MYLAN INDIA PRIVATE LIMITED (IN) | 2012-05-03 | — | — | US | disclosed |
| WO-2012042534-A2 | PROCESSES FOR THE PREPARATION OF R-SITAGLIPTIN AND INTERMEDIATES THEREOF | GLENMARK GENERICS LIMITED (IN) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012042534-A2 | PROCESSES FOR THE PREPARATION OF R-SITAGLIPTIN AND INTERMEDIATES THEREOF | GLENMARK GENERICS LIMITED (IN) | 2012-04-05 | — | — | WO | disclosed |
| EP-2430025-A1 | SITAGLIPTIN SYNTHESIS | Generics [UK] Limited (GB) | 2012-03-21 | — | — | EP | disclosed |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| WO-2011040717-A2 | METHOD FOR PREPARING INTERMEDIATE OF SITAGLIPTIN USING CHIRAL OXIRANE | HANMI HOLDINGS CO., LTD. (KR) | 2011-04-07 | — | — | WO | disclosed |
| WO-2010131025-A1 | SITAGLIPTIN SYNTHESIS | GENERICS [UK] LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010097420-A1 | PROCESS FOR THE PREPARATION OF A CHIRAL BETA AMINOACID DERIVATIVE AND INTERMEDIATES THEREOF | Esteve Química, S.A. (ES) | 2010-09-02 | — | — | WO | disclosed |
| EP-2223923-A1 | Process for the preparation of a chiral beta aminoacid derivative and intermediates thereof | Esteve Química, S.A. (ES) | 2010-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DPP4, DPP3, DPP7 | DPP4 1/4885PIN1 232/4885DPP7 3/4885 |
| US-20180086765-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | DPP4, DPP7, DPP9 | DPP4 1/4885PIN1 709/4885DPP7 2/4885 |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DPP4, DPP3, DPP7 | DPP4 1/4885PIN1 138/4885DPP7 3/4885 |
| US-20120108598-A1 | SITAGLIPTIN SYNTHESIS | DPP4, DPP7, DPP3 | DPP4 1/4885PIN1 743/4885DPP7 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.