Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433727 | 0.96 | DPP4 (0.34) | AGTR1DPP4CDK7CDK9 | |
| SCHEMBL7445226 | 0.93 | DPP4 (0.35) | AGTR1DPP4 | |
| SCHEMBL7443560 | 0.87 | DPP4 (0.36) | DPP4 | |
| SCHEMBL7487675 | 0.86 | DPP4 (0.36) | DPP4 | |
| SCHEMBL7442649 | 0.84 | DPP4 (0.38) | AGTR1DPP4CCNT1CDK7CDK9 | |
| SCHEMBL7438339 | 0.83 | AGTR1 (0.44) | AGTR1CCNT1CDK7CDK9CCNH | |
| SCHEMBL7439812 | 0.81 | GSK3B (0.32) | AGTR1 | |
| SCHEMBL7447153 | 0.81 | AGTR1 (0.37) | AGTR1 | |
| SCHEMBL7438628 | 0.81 | AGTR1 (0.32) | AGTR1 | |
| SCHEMBL7436076 | 0.81 | AGTR1 (0.31) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |