Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CBX7 | O95931 | 1/20 | 0.37 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.37 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.37 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYBB | P04839 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427902 | 0.76 | PGR (0.50) | PGRIDO1IP6K1NQO2PDK2 | |
| SCHEMBL7438527 | 0.75 | PGR (0.52) | PGRIDO1IP6K1NQO2PDK2 | |
| SCHEMBL20268320 | 0.73 | IP6K1 (0.55) | PGRIP6K1PDE3BPDE3A | |
| SCHEMBL20268826 | 0.73 | IP6K1 (0.55) | PGRIP6K1PDE3BPDE3A | |
| SCHEMBL1764545 | 0.71 | HDAC3 (0.54) | PGRIP6K1GAAMAPTNPC1 | |
| SCHEMBL1874397 | 0.68 | PGR (0.55) | PGRIP6K1PDK2PDE3BPDE3A | |
| SCHEMBL31117105 | 0.68 | PGR (0.51) | PGRPDK2CBX7CDYL2CDYL | |
| SCHEMBL9462366 | 0.68 | KDM4E (0.55) | PGRPDE3BPDE3ANPC1 | |
| SCHEMBL7379550 | 0.68 | PGR (0.51) | PGRPDK2CBX7CDYL2CDYL | |
| SCHEMBL27076405 | 0.68 | MAPT (0.45) | PGRGAAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933336-A | Thiadiazinone, oxadiazinone and triazinone derivatives, and their use for treating acute or chronic heart disease | LABORATOIRES SOBIO S.A. (FR) | 1990-06-12 | — | — | US | disclosed |
| EP-0303418-A2 | Substituted indolones, useful in the treatment of heart or asthmatic diseases | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1989-02-15 | — | — | EP | disclosed |