Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427181 | 0.84 | DGAT1 (0.31) | DGAT1 | |
| SCHEMBL2328858 | 0.83 | MAPT (0.37) | MAPTCYP2C19POLBTDP1 | |
| SCHEMBL7448330 | 0.79 | — | — | |
| SCHEMBL14385386 | 0.77 | DGAT1 (0.34) | POLBDGAT1ALDH1A1 | |
| SCHEMBL28728319 | 0.76 | MAPT (0.47) | MAPTCYP2C19POLBTDP1DGAT1 | |
| SCHEMBL11918118 | 0.74 | DGAT1 (0.36) | DGAT1LMNA | |
| SCHEMBL7439027 | 0.74 | DGAT1 (0.32) | DGAT1LMNA | |
| SCHEMBL7433180 | 0.73 | CYP2C19 (0.36) | MAPTCYP2C19POLBTDP1DGAT1 | |
| SCHEMBL9924097 | 0.73 | DGAT1 (0.35) | DGAT1 | |
| SCHEMBL27853216 | 0.73 | MAPT (0.36) | MAPTCYP2C19POLBTDP1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066666-A | OPTIONALLY N-SUBSTITUTED 3-MONO- AND DI-SUBSTITUTED 2-PYRROLIDINONES AND THIOLACTAM ANALOGS; TREAT SEIZURES, ANXIETY, AND ENHANCING 4-AMINOBUTYRIC ACID (GABA)-INDUCED CHLORIDE CURRENTS AT GABA RECEPTOR/IONOPHORE COMPLEX | WASHINGTON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| US-5776959-A | Anticonvulsant and anxiolytic lactam and thiolactam derivatives | WASHINGTON UNIVERSITY (US) | 1998-07-07 | — | — | US | disclosed |