Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10710245 | 1.00 | PPARG (0.54) | PPARGEPHX2MMP8ACECYP3A4 | |
| SCHEMBL7437561 | 0.89 | ACE (0.57) | PPARGEPHX2ACEMME | |
| SCHEMBL7437564 | 0.89 | ACE (0.57) | PPARGEPHX2ACEMME | |
| SCHEMBL7444122 | 0.86 | ACE (0.67) | PPARGEPHX2ACEMME | |
| SCHEMBL7444128 | 0.86 | ACE (0.67) | PPARGEPHX2ACEMME | |
| SCHEMBL7442461 | 0.83 | PPARG (0.52) | PPARGEPHX2MMP8ACEPPARA | |
| SCHEMBL10821666 | 0.83 | PPARG (0.52) | PPARGEPHX2MMP8ACEPPARA | |
| SCHEMBL6618690 | 0.79 | PPARG (0.51) | PPARGEPHX2MMP8PPARA | |
| SCHEMBL7436656 | 0.78 | CYP1A2 (0.61) | PPARGEPHX2MMP8 | |
| SCHEMBL9622141 | 0.78 | CYP1A2 (0.61) | PPARGEPHX2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5096925-A | N-substituted butyramide derivatives | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | disclosed |
| US-4939261-A | ANALGESICS, ANTIDEPRESSANTS, HYPOTENSIVE AGENTS, NEUROLEPTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0185079-B1 | N-SUBSTITUTED BUTYRAMIDE DERIVATIVES | CIBA-GEIGY AG (CH) | 1988-10-19 | — | — | EP | disclosed |
| EP-0185079-A1 | — | CIBA GEIGY AG | 1986-06-25 | — | — | EP | disclosed |
| WO-1986000066-A1 | N-SUBSTITUTED BUTYRAMIDE DERIVATIVES | CIBA-GEIGY AG (CH) | 1986-01-03 | — | — | WO | disclosed |