Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.43 |
| ▸ | CPA3 | P15088 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27541485 | 0.88 | PPARG (0.53) | PPARGEPHX2MMP8FOLH1MEN1 | |
| SCHEMBL15479082 | 0.88 | PPARG (0.58) | PPARGEPHX2MMP8FOLH1MEN1 | |
| SCHEMBL9119426 | 0.85 | FOLH1 (0.54) | MMP8FOLH1KMT2AMMP1MMP3 | |
| SCHEMBL9118777 | 0.85 | FOLH1 (0.54) | MMP8FOLH1KMT2AMMP1MMP3 | |
| SCHEMBL10521821 | 0.84 | MMP8 (0.61) | PPARGEPHX2MMP8FOLH1MEN1 | |
| SCHEMBL18065695 | 0.83 | EPHX2 (0.54) | PPARGEPHX2MMP8MEN1NPC1 | |
| SCHEMBL3184765 | 0.83 | PPARG (0.57) | PPARGEPHX2MMP8FOLH1MEN1 | |
| SCHEMBL10815689 | 0.82 | SMN1; SMN2 (0.50) | PPARGEPHX2MMP8MEN1NPC1 | |
| SCHEMBL9554885 | 0.82 | CPA3 (0.66) | PPARGEPHX2MMP8FOLH1MEN1 | |
| SCHEMBL7296084 | 0.82 | FOLH1 (0.50) | FOLH1KMT2ACYP1A2TDP1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683781-B1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | METABASIS THERAPEUTICS INC (US) | 2004-04-21 | — | — | EP | disclosed |
| US-5731432-A | Inhibitors of adenosine monophosphate deaminase | GENSIA SICOR INC. (US) | 1998-03-24 | — | — | US | disclosed |
| EP-0683781-A4 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE. | GENSIA PHARMA (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0683781-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA PHARMACEUTICALS, INC. (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018200-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |