Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445273 | 0.90 | PCSK9 (0.43) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7437818 | 0.88 | PCSK9 (0.44) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7446965 | 0.88 | PCSK9 (0.43) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL8799176 | 0.88 | PCSK9 (0.43) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7439319 | 0.88 | LMNA (0.47) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7446971 | 0.88 | PCSK9 (0.43) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL8799181 | 0.88 | PCSK9 (0.43) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7442836 | 0.87 | MAPT (0.45) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL8798819 | 0.87 | PCSK9 (0.41) | PCSK9LMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7445277 | 0.86 | LMNA (0.43) | PCSK9LMNAALDH1A1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |