Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3869454 | 0.98 | KMT2A (0.41) | MAOAMAOBKMT2AADRA2AADRA2B | |
| SCHEMBL31598494 | 0.82 | MEN1 (0.44) | MAOAMAOBKMT2AADRA2AADRA2B | |
| SCHEMBL28701448 | 0.81 | CCNA2 (0.45) | MAOAMAOBADRA2AADRA2BADRA2C | |
| SCHEMBL11641022 | 0.81 | NPC1 (0.48) | MAOAMAOBKMT2AADRA2AADRA2B | |
| SCHEMBL10430601 | 0.81 | ADRA2A (0.44) | KMT2AADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL3310894 | 0.80 | MEN1 (0.45) | KMT2AADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL29648993 | 0.79 | ADRA2A (0.50) | KMT2AADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL12969952 | 0.78 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHTR2AHTR2C | |
| SCHEMBL11645634 | 0.77 | NPC1 (0.51) | MAOAMAOBKMT2AKDM4EHSD17B10 | |
| SCHEMBL4431219 | 0.76 | GRM5 (0.44) | MAOAMAOBKDM4EHSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385237-A2 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |