Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 5/20 | 0.48 |
| ▸ | CASP3 | P42574 | 13/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 11/20 | 0.38 |
| ▸ | CASP7 | P55210 | 4/20 | 0.38 |
| ▸ | CASP6 | P55212 | 5/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437728 | 0.93 | CASP1 (0.49) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL7441956 | 0.92 | CASP1 (0.48) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL7438695 | 0.89 | CASP1 (0.46) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL7427145 | 0.88 | CASP1 (0.49) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL7680380 | 0.87 | CASP1 (0.46) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL7431671 | 0.86 | CASP1 (0.49) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL7436074 | 0.86 | CASP1 (0.48) | CASP1CASP3CASP8CASP7CASP6 | |
| Hydrochloric Acid SCHEMBL7438675 | 0.86 | CASP1 (0.47) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL7429909 | 0.85 | CASP1 (0.48) | CASP1CASP3CASP8CASP7HRH1 | |
| SCHEMBL7439311 | 0.85 | CASP1 (0.48) | CASP1CASP3CASP8CASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | claimed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |