Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012855 | 0.85 | LMNA (0.46) | LMNATSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL24083543 | 0.80 | — | — | |
| SCHEMBL229792 | 0.80 | TSHR (0.50) | LMNATSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL29467311 | 0.79 | LMNA (0.47) | LMNATSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL181911 | 0.79 | LMNA (0.47) | LMNATSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL11133563 | 0.79 | LMNA (0.42) | LMNATSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL28875912 | 0.78 | LMNA (0.48) | LMNATSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL28315849 | 0.78 | LMNA (0.48) | LMNATSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL18152012 | 0.78 | LMNA (0.48) | LMNATSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL28727541 | 0.78 | LMNA (0.48) | LMNATSHRMAPTHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101535274-B | Process for preparing difluoromethylpyrazolyl carboxylates | BASF SE | 2012-09-05 | — | — | CN | disclosed |
| CN-101535274-A | Process for preparing difluoromethylpyrazolyl carboxylates | BASF SE (DE) | 2009-09-16 | — | — | CN | disclosed |
| US-4686217-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS | FISONS PLC (GB) | 1987-08-11 | — | — | US | disclosed |
| US-4607041-A | CARDIOTONIC AGENTS | FISONS PLC (GB) | 1986-08-19 | — | — | US | disclosed |
| EP-0125803-A2 | Pharmaceutically active dihydropyridines | FISONS plc (GB) | 1984-11-21 | — | — | EP | disclosed |