Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 2/20 | 0.45 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 4/20 | 0.44 |
| ▸ | DRD5 | P21918 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046308 | 0.93 | PDE3B (0.54) | PDE3BPDE3AMETAP1BCL2DRD1 | |
| SCHEMBL13506283 | 0.81 | PDE3B (0.55) | PDE3BPDE3AMETAP1DRD1DRD5 | |
| SCHEMBL12079387 | 0.80 | PDE3B (0.61) | PDE3BPDE3AMETAP1BCL2GAA | |
| SCHEMBL2607471 | 0.78 | DRD1 (0.62) | METAP1BCL2DRD1DRD5DRD2 | |
| SCHEMBL7443640 | 0.77 | DRD2 (0.44) | DRD2DRD3DRD4 | |
| SCHEMBL2062199 | 0.77 | DRD1 (0.54) | METAP1BCL2DRD1DRD5DRD2 | |
| SCHEMBL30468429 | 0.75 | GAA (0.50) | PDE3BPDE3AMETAP1DRD1DRD5 | |
| SCHEMBL227544 | 0.75 | GAA (0.50) | PDE3BPDE3AMETAP1DRD1DRD5 | |
| SCHEMBL29724095 | 0.75 | MAOB (0.58) | PDE3BPDE3AMAOBMAOA | |
| SCHEMBL703728 | 0.75 | MAOB (0.58) | PDE3BPDE3AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403578-B1 | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| EP-0674623-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014776-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |