Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.54 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7443954 | 0.99 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DSLC40A1 | |
| SCHEMBL5775461 | 0.86 | SLC40A1 (0.48) | PDE4APDE4BPDE4CPDE4DSLC40A1 | |
| SCHEMBL418337 | 0.84 | SLC40A1 (0.57) | PDE4APDE4BPDE4CPDE4DSLC40A1 | |
| SCHEMBL4038293 | 0.84 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6182554 | 0.81 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7449817 | 0.80 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DSLC40A1 | |
| SCHEMBL5775465 | 0.79 | SLC40A1 (0.48) | PDE4APDE4BPDE4CPDE4DSLC40A1 | |
| SCHEMBL4037497 | 0.79 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4035513 | 0.78 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5257490 | 0.78 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |