Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438615 | 0.93 | AGTR1 (0.42) | GSK3BAGTR1CDK2 | |
| SCHEMBL7436086 | 0.93 | GSK3B (0.41) | GSK3BAGTR1 | |
| SCHEMBL7436199 | 0.93 | GSK3B (0.41) | GSK3BAGTR1CDK2 | |
| SCHEMBL7440954 | 0.91 | GSK3B (0.39) | GSK3BAGTR1CDK2 | |
| SCHEMBL7440327 | 0.90 | AGTR1 (0.39) | GSK3BAGTR1 | |
| SCHEMBL7445211 | 0.89 | AGTR1 (0.52) | GSK3BAGTR1 | |
| SCHEMBL7442658 | 0.85 | GSK3B (0.56) | GSK3BAGTR1CDK2 | |
| SCHEMBL7434200 | 0.84 | KMT2A (0.40) | GSK3BAGTR1CDK2 | |
| SCHEMBL7440053 | 0.84 | AGTR1 (0.39) | GSK3BAGTR1 | |
| SCHEMBL7442152 | 0.84 | AGTR1 (0.37) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |