Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | CASP3 | P42574 | 11/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 9/20 | 0.39 |
| ▸ | CASP6 | P55212 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433121 | 0.94 | CASP1 (0.45) | CASP1CASP3CASP8CASP6TP53 | |
| SCHEMBL7440025 | 0.93 | CASP1 (0.48) | CASP1CASP3CASP8CASP6ALDH1A1 | |
| SCHEMBL7432201 | 0.90 | CASP1 (0.46) | CASP1CASP3CASP8CASP6KDM4E | |
| SCHEMBL7431066 | 0.87 | CASP1 (0.48) | CASP1CASP3CASP8KDM4ETP53 | |
| SCHEMBL7439311 | 0.87 | CASP1 (0.48) | CASP1CASP3CASP8CASP6KDM4E | |
| SCHEMBL7436443 | 0.87 | CASP1 (0.46) | CASP1CASP3CASP8CASP6ALDH1A1 | |
| SCHEMBL7432214 | 0.86 | CASP1 (0.48) | CASP1CASP3CASP8CASP6TP53 | |
| SCHEMBL7440398 | 0.86 | CASP1 (0.52) | CASP1CASP3CASP8CASP6USP2 | |
| SCHEMBL7445736 | 0.86 | CASP1 (0.49) | CASP1CASP3CASP8CASP6KDM4E | |
| SCHEMBL7434545 | 0.85 | CASP1 (0.47) | CASP1CASP3CASP8CASP6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | claimed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |