Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | CEL | P19835 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11651890 | 0.98 | CYP1A2 (0.52) | CYP1A2SIGMAR1EPHX1GPR84KDM5A | |
| SCHEMBL8838698 | 0.93 | CYP1A2 (0.54) | CYP1A2SIGMAR1EPHX1GPR84KDM5A | |
| SCHEMBL9670510 | 0.91 | SIGMAR1 (0.54) | CYP1A2SIGMAR1EPHX1GPR84KDM5A | |
| SCHEMBL2763855 | 0.85 | CYP1A2 (0.48) | CYP1A2SIGMAR1EPHX1CEL | |
| SCHEMBL4182684 | 0.82 | — | — | |
| SCHEMBL8171567 | 0.76 | CYP1A2 (0.56) | CYP1A2SIGMAR1EPHX1CEL | |
| SCHEMBL8117690 | 0.76 | CYP1A2 (0.50) | CYP1A2SIGMAR1EPHX1KDM5APHF8 | |
| SCHEMBL9190697 | 0.76 | SIGMAR1 (0.70) | CYP1A2SIGMAR1EPHX1KDM5APHF8 | |
| SCHEMBL5614191 | 0.76 | SIGMAR1 (0.70) | CYP1A2SIGMAR1EPHX1KDM5APHF8 | |
| SCHEMBL10579794 | 0.76 | CYP1A2 (0.68) | CYP1A2SIGMAR1EPHX1CEL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632036-B1 | Amide derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO CO (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5614550-A | ANTICHOLESTEROL AGENTS OR ARTERIOSCLEROSIS AGENTS FOR HUMANS | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| US-5534529-A | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0632036-A2 | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1995-01-04 | — | — | EP | disclosed |
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| US-4652551-A | PEPTIDE, HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0172346-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |