Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11349942 | 0.82 | L3MBTL1 (0.66) | L3MBTL1KDM4EPKMHTTTSHR | |
| SCHEMBL2149244 | 0.81 | L3MBTL1 (0.65) | L3MBTL1KDM4EPKMHTTTSHR | |
| SCHEMBL4614755 | 0.81 | L3MBTL1 (0.69) | L3MBTL1KDM4EPKMHTTTSHR | |
| SCHEMBL4616542 | 0.81 | L3MBTL1 (0.64) | L3MBTL1KDM4EPKMHTTTSHR | |
| SCHEMBL4615852 | 0.81 | L3MBTL1 (0.64) | L3MBTL1KDM4EPKMHTTTSHR | |
| SCHEMBL7022286 | 0.80 | L3MBTL1 (0.71) | L3MBTL1KDM4EPKMHTTNPC1 | |
| SCHEMBL7822750 | 0.80 | HTT (1.00) | L3MBTL1KDM4EPKMHTTTSHR | |
| SCHEMBL11350777 | 0.78 | L3MBTL1 (0.66) | L3MBTL1KDM4EPKMHTTTSHR | |
| SCHEMBL318427 | 0.78 | L3MBTL1 (0.68) | L3MBTL1KDM4EPKMTSHRNPC1 | |
| SCHEMBL318582 | 0.78 | L3MBTL1 (0.64) | L3MBTL1HTTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703071-A | Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0546102-B1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | UPJOHN CO (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5594144-A | TREATING CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0546102-A1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES. | UPJOHN CO (US) | 1993-06-16 | — | — | EP | disclosed |
| WO-1992004338-A1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | THE UPJOHN COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |