Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447971 | 0.82 | ACE (0.47) | MMEACEKDM4EMAPTTHRB | |
| SCHEMBL29433928 | 0.77 | MME (0.47) | MMEACEKDM4EMAPTTHRB | |
| SCHEMBL2872479 | 0.76 | MME (0.68) | MMEACEKDM4EMAPTTHRB | |
| SCHEMBL2872485 | 0.76 | MME (0.68) | MMEACEKDM4EMAPTTHRB | |
| SCHEMBL9068733 | 0.76 | MME (0.55) | MMEACE | |
| SCHEMBL9068732 | 0.76 | MME (0.55) | MMEACE | |
| SCHEMBL9068734 | 0.76 | MME (0.55) | MMEACE | |
| SCHEMBL9068731 | 0.76 | MME (0.55) | MMEACE | |
| SCHEMBL11324786 | 0.73 | MME (0.52) | MMEACEPDCD1LG2CD274CA2 | |
| SCHEMBL8528255 | 0.73 | MME (0.52) | MMEACEPDCD1LG2CD274CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989012627-A1 | S-NITROSO DERIVATIVES OF ACE INHIBITORS AND THE USE THEREOF | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1989-12-28 | — | — | WO | claimed |
| US-5536723-A | VASODILATORS | BRIGHAM & WOMEN'S HOSPITAL (US) | 1996-07-16 | — | — | US | disclosed |
| US-5356890-A | Angiotensin converting enzyme | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1994-10-18 | — | — | US | disclosed |
| US-5187183-A | Cardiovascular-renal disease; anticoagulants, hypotensive agents; vasodilators; pregnancy toxemia; sclerodema; angiotensin-converting-enzyme inhibitors | BRIGHAM & WOMEN'S HOSPITAL (US) | 1993-02-16 | — | — | US | disclosed |
| US-5025001-A | S-nitroso derivatives of ACE inhibitors and the use thereof | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1991-06-18 | — | — | US | disclosed |
| US-5002964-A | S-nitrosocaptopril compounds and the use thereof | BRIGHAM & WOMEN'S HOSPITAL (US) | 1991-03-26 | — | — | US | disclosed |
| WO-1989012627-A1 | S-NITROSO DERIVATIVES OF ACE INHIBITORS AND THE USE THEREOF | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1989-12-28 | — | — | WO | disclosed |