Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442737 | 0.90 | CSNK2A1 (0.40) | KDM4EALDH1A1GLAHPGDMAPK1 | |
| SCHEMBL7446388 | 0.89 | MAPT (0.38) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL7440248 | 0.87 | KDM4E (0.45) | KDM4EALDH1A1GLAHPGDMAPK1 | |
| SCHEMBL7448815 | 0.84 | TP53 (0.35) | MAPTTP53AGTR1AGTR2MAPK8 | |
| SCHEMBL7440260 | 0.82 | KMT2A (0.52) | KDM4EALDH1A1GLAHPGDMAPK1 | |
| SCHEMBL7437565 | 0.81 | MAPT (0.38) | MAPTTP53AGTR1AGTR2MAPK8 | |
| SCHEMBL7444163 | 0.80 | AGTR1 (0.32) | MAPTTP53AGTR1AGTR2MAPK8 | |
| SCHEMBL7427170 | 0.78 | CSNK2A1 (0.35) | KDM4EALDH1A1GLAHPGDMAPK1 | |
| SCHEMBL7437420 | 0.78 | AGTR1 (0.33) | MAPK1HSD17B10AGTR1AGTR2CDK2 | |
| SCHEMBL7434028 | 0.78 | AGTR1 (0.34) | KDM4EALDH1A1GLAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |