Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 16/20 | 0.69 |
| ▸ | HTR1B | P28222 | 13/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314559 | 0.82 | HTR1D (1.00) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL7437193 | 0.81 | HTR1D (0.78) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL7439194 | 0.77 | HTR1D (0.84) | HTR1DHTR1BHTR1A | |
| SCHEMBL7448912 | 0.77 | HTR1D (0.84) | HTR1DHTR1BHTR1A | |
| SCHEMBL8124390 | 0.75 | HTR1D (0.83) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL8316699 | 0.75 | HTR1D (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL8875034 | 0.74 | HTR1D (0.84) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL9055626 | 0.73 | HTR1D (0.54) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL7441439 | 0.73 | HTR1D (0.69) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL9045334 | 0.72 | HTR1D (0.62) | HTR1DHTR1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |