Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.79 |
| ▸ | CASP1 | P29466 | 4/20 | 0.79 |
| ▸ | CASP7 | P55210 | 4/20 | 0.79 |
| ▸ | POLB | P06746 | 3/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | HPGD | P15428 | 4/20 | 0.69 |
| ▸ | USP2 | O75604 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5476396 | 0.85 | KDM4E (0.68) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL3323110 | 0.82 | KDM4E (0.64) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL3327953 | 0.80 | KDM4E (0.56) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL5332407 | 0.80 | KDM4E (0.68) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL3324953 | 0.79 | ALDH1A1 (0.53) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL3323761 | 0.79 | KDM4E (0.62) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL3330007 | 0.79 | KDM4E (0.54) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL5309983 | 0.78 | KDM4E (0.68) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL12135697 | 0.78 | KDM4E (0.76) | KDM4EHSD17B10CASP1CASP7POLB | |
| SCHEMBL13333412 | 0.78 | KDM4E (0.55) | KDM4EHSD17B10CASP1CASP7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | ANGIOGENEX | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | BRAF, MAPK1, RAF1 | KDM4E 1876/4885HSD17B10 3456/4885CASP1 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.