Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831221 | 0.82 | KDM4E (0.45) | HSD17B10ALDH1A1HPGDSOS1CA1 | |
| SCHEMBL1994444 | 0.77 | MAPT (0.43) | HSD17B10ALDH1A1HPGDTSHRSOS1 | |
| SCHEMBL6646364 | 0.76 | KDM4E (0.39) | HSD17B10ALDH1A1HPGDTSHRSOS1 | |
| SCHEMBL6642984 | 0.74 | TSHR (0.44) | HSD17B10ALDH1A1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL6644948 | 0.73 | KDM4E (0.47) | HSD17B10ALDH1A1HPGDTSHRCA1 | |
| SCHEMBL6647182 | 0.73 | MAPT (0.40) | HSD17B10ALDH1A1HPGDTSHRSOS1 | |
| SCHEMBL2165984 | 0.72 | GAA (0.34) | HPGDTSHRSMN1; SMN2USP2CDK1 | |
| SCHEMBL2166677 | 0.72 | KMT2A (0.35) | HSD17B10ALDH1A1HPGDTSHRCA2 | |
| SCHEMBL7595029 | 0.71 | SOS1 (0.49) | HSD17B10ALDH1A1HPGDTSHRSOS1 | |
| SCHEMBL7491095 | 0.71 | SOS1 (0.45) | HSD17B10ALDH1A1HPGDTSHRSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |