Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 17/20 | 0.52 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743692 | 0.90 | LIPE (0.52) | LIPEMETAP2 | |
| SCHEMBL746801 | 0.90 | LIPE (0.56) | LIPE | |
| SCHEMBL744714 | 0.85 | LIPE (0.52) | LIPEMETAP2 | |
| SCHEMBL744731 | 0.84 | LIPE (0.54) | LIPE | |
| SCHEMBL746967 | 0.84 | LIPE (0.54) | LIPEMETAP2 | |
| SCHEMBL746787 | 0.80 | LIPE (0.55) | LIPEMETAP2 | |
| SCHEMBL745199 | 0.80 | LIPE (0.58) | LIPE | |
| SCHEMBL748194 | 0.79 | LIPE (0.64) | LIPEMETAP2 | |
| SCHEMBL3737971 | 0.79 | LIPE (0.56) | LIPE | |
| SCHEMBL745608 | 0.78 | LIPE (0.58) | LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430023-A1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-21 | — | — | EP | claimed |
| US-8329904-B2 | Azacyclic derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329904-B2 | Azacyclic derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | disclosed |
| EP-2430023-A1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130665-A1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | WO | disclosed |