Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.54 |
| ▸ | PDE4A | P27815 | 5/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70933 | 0.89 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL70934 | 0.89 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL4637156 | 0.78 | ALDH1A1 (0.62) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL8482644 | 0.77 | PDE4A (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8483751 | 0.77 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8483747 | 0.77 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1388370 | 0.77 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL1074318 | 0.77 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL1388372 | 0.77 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL31619157 | 0.76 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4CPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935978-A | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group | RHONE-POULENC RORER LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |
| US-5840724-A | COMPOUNDS FOR TUMOR NECROSIS FACTOR OR ENZYME INHIBITORS OF PHOSPHODIESTERASES | RHONE-POULENC RORER LIMITED (GB) | 1998-11-24 | — | — | US | disclosed |
| US-5698711-A | INHIBITORS OF TUMOR NECROSIS FACTOR, CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE PHOSPHODIESTERASE AND EOSINOPHILS | RHONE-POULENC RORER LIMITED (GB) | 1997-12-16 | — | — | US | disclosed |
| US-5679696-A | FOR INHIBITING TUMOR NECROSIS FACTOR; ENZYME INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1997-10-21 | — | — | US | disclosed |