Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277316 | 0.89 | PDE5A (0.70) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7380061 | 0.84 | PDE5A (0.70) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7431503 | 0.83 | USP2 (0.68) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7426676 | 0.82 | PDE5A (0.61) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7431560 | 0.82 | PDE5A (0.64) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7405705 | 0.81 | PDE5A (0.77) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7433013 | 0.81 | PDE5A (0.73) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7609102 | 0.80 | LATS1 (0.62) | MEN1KMT2AGBA1TSHRHPGD | |
| SCHEMBL7437119 | 0.80 | PDE5A (0.74) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7437411 | 0.80 | PDE5A (0.69) | PDE5APTGS1TBXAS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | claimed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |